Original Articles
14 February 2025
Vol. 42 No. 2 (2020)
https://doi.org/10.4081/gimle.447

EFFICACY OF SODIUM HYPOCHLORITE IN THE DEGRADATION ANTINEOPLASTIC DRUGS BY NMR SPECTROSCOPY

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Antineoplastics, degradation, NMR, sodium hypochlorite.
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Authors

Fabio Sciubba
Department of Chemistry, University of Rome La Sapienza, Rome, Italy.
Mariangela Spagnoli
Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Monte Porzio Catone (RM), Italy.
Sergio Iavicoli
Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Monte Porzio Catone (RM), Italy.
Gaia Asaro
A.R.N.A.S. Ospedali Civico Di Cristina Benfratelli, Palermo, Italy.
Alessio De Luca
Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
Gaspare Guglielmi
A.O.R.N. Antonio Cardarelli, Farmacia, Napoli, Italy.
Maurizio Delfini
mauriziodelfini@uniroma1.it
Department of Chemistry, University of Rome La Sapienza, Rome, Italy.

Antineoplastic drugs are used to treat cancer, having their therapeutic effect by inhibiting the cell division process. Although cancer cells, due to their rapid growth, are more sensitive to the toxic effects of chemotherapeutic agents, healthy cells and tissues may also be damaged. Many studies show acute and chronic toxicity both in patients treated with chemotherapy and in exposed workers. In fact, exposure to these substances can also be linked to the formation of different types of secondary tumors. The International Agency on Research on Cancer (IARC) included some antineplastic drugs in Group 1 (carcinogenic to humans), in Group 2A (probable carcinogens for In recent years, many studies have evidenced the presence of antineoplastic drug contamination on work surfaces, materials and floors and based on these observations, international and national guidelines have been published to limit occupational exposure, with particular attention to procedures post-preparation of chemotherapy to limit as much as possible the accumulation of contaminated residues.
The aim of the following study is to determine the effectiveness of the degradation of four antineoplastic drugs: 5-fluorouracil, azacitidine, cytarabine and irinotecan using a low concentration of sodium hypochlorite solution (0.115%). The analytical platform used to monitor the degradation course of the substances under examination was hydrogen nuclear magnetic spectroscopy (H NMR). In the same experimental conditions the effectiveness of the degradation of the same antineoplastic drugs with a 99.9% ethanol solution was also evaluated. The study showed that the best degradation efficiency (> 90% ) is obtained with the hypochlorite solution after 15 minutes.

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EFFICACY OF SODIUM HYPOCHLORITE IN THE DEGRADATION ANTINEOPLASTIC DRUGS BY NMR SPECTROSCOPY. (2025). Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 42(2), 109-120. https://doi.org/10.4081/gimle.447
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