ATTI 82° CONGRESSO NAZIONALE SIML
25 September 2019
Vol. 41 No. 4 (2019)
https://doi.org/10.4081/gimle.521

[Nanoparticle exposure in research labs]

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Authors

Ivo Iavicoli
Dipartimento di Sanità Pubblica, Sezione di Medicina del Lavoro, Università degli Studi di Napoli Federico II, Napoli, Italy.
Veruska Leso
Dipartimento di Sanità Pubblica, Sezione di Medicina del Lavoro, Università degli Studi di Napoli Federico II, Napoli, Italy.
Luca Fontana
Dipartimento di Medicina, Epidemiologia, Igiene del Lavoro e Ambientale, Monte Porzio Catone (RM), Italy.

Aims. A growing number of workers are employed in research laboratories where nanomaterials (NMs) are synthesized, characterized, processed and investigated for their physico-chemical and toxicological properties. To adequately evaluate occupational risks in such contexts, a suitable exposure assessment is necessary.
Methods. A critical review of the scientific and grey literature on NM exposure in laboratories has been performed.
Results. The evaluation of the exposure, in general, includes a preliminary analysis of the working processes and of the features of NMs employed. Environmental and personal monitoring can be used for a quantitative assessment of the exposure, although the current uncertainties relating to the metrological parameters to be measured and the occupational exposure limits to be compared with collected data make the interpretation of the results and the definition of shared sampling strategies a challenging issue.
Conclusions. To date, qualitative information on NM exposure can be used in "control banding" instruments useful for the precautionary assessment and management of risks in research laboratories involved with NMs. Future NM environmental and personal exposure assessments should be pursued to define appropriate monitoring strategies and guide the adoption of appropriate preventive measures to protect the health of workers.

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1) NIOSH, National Institute for Occupational Safety and Health. Approaches to safe nanotechnology: Managing the Health and Safety Concerns Associated with Engineered Nanomaterials. Centers for Disease Control and Prevention, 2009. Disponibile al sito https://www.cdc.gov/niosh/docs/2009-125/pdfs/2009-125.pdf.
2) Leso V, Fontana L, Mauriello MC, et al. Occupational Risk Assessment of Engineered Nanomaterials: Limits, Challenges and Opportunities. Current Nanosci 2017; 13: 55-78. DOI: https://doi.org/10.2174/1573413712666161017114934
3) NIOSH, National Institute for Occupational Safety and Health. General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories. Centers for Disease Control and Prevention, 2012. Disponibile al sito https://ehs.psu.edu/sites/ehs/files/ general_safe_practices_for_working_w_engineered_nanomaterials in_research_laboratories_niosh_publication_no._2012-147.pdf 4) NRC, National Research Council. Risk Assessment in the Federal Government: Managing the Process. Committee on the Institutional Means for Assessment of Risks to Public Health, Commission on Life Sciences. 1983. National Academy Press, Washington D.C. 19s83 (ISBN: 0-309-03349-7).
5) Savolainen K, Alenius H, Norppa H, et al. Risk assessment of engineered nanomaterials and nanotechnologies-a review. Toxicology 2010; 269(2-3): 92-104. DOI: https://doi.org/10.1016/j.tox.2010.01.013
6) Imhof C, Clark K, Meyer T, et al. Research and development-where people are exposed to nanomaterials. J Occup Health. 2015; 57(2): 179-188. DOI: https://doi.org/10.1539/joh.14-0189-FS
7) Johnson DR, Methner MM, Kennedy AJ, et al. Potential for occupational exposure to engineered carbon-based nanomaterials in environmental laboratory studies. Environ Health Perspect 2010; 118(1): 49-54. DOI: https://doi.org/10.1289/ehp.0901076
8) Methner M, Hodson L, Dames A, et al. Nanoparticle Emission Assessment Technique (NEAT) for the identification and measurement of potential inhalation exposure to engineered nanomaterials-Part B: Results from 12 field studies. J Occup Environ Hyg 2010; 7(3): 163-176. 9) Eastlake AC, Beaucham C, Martinez KF, et al. Refinement of the Nanoparticle Emission Assessment Technique into the Nanomaterial Exposure Assessment Technique (NEAT 2.0). J Occup Environ Hyg 2016; 13(9): 708-717. DOI: https://doi.org/10.1080/15459620903508066
10) Asbach C, Alexander C, Clavaguera S, et al. Review of measurement techniques and methods for assessing personal exposure to airborne nanomaterials in workplaces. Sci Total Environ 2017; 603-604:793-806. 11) Asbach C, Neumann V, Monz C, et al. On the effect of wearing personal nanoparticle monitors on the comparability of personal exposure measurements. Environ Sci Nano 2017; 4: 233-243. 12) lavicoli I, Fontana L, Pingue P, et al. Assessment of occupational exposure to engineered nanomaterials in research laboratories using personal monitors. Sci Total Environ 2018; 627: 689-702. DOI: https://doi.org/10.1016/j.scitotenv.2018.01.260
13) Groso A, Petri-Fink A, Rothen-Rutishauser B, et al. Engineered nanomaterials: toward effective safety management in research laboratories. J Nanobiotechnology 2016; 14: 21. DOI: https://doi.org/10.1186/s12951-016-0169-x
14) NIOSH, National Institute for Occupational Safety and Health. Occupational Exposure to Titanium Dioxide. No. 2011-160. Centers for Disease Control and Prevention, 2011. Disponibile al sito https://www.cdc.gov/niosh/docs/2011-160/pdfs/2011-160.pdf.
15) NIOSH, National Institute for Occupational Safety and Health. Occupational exposure to carbon nanotubes and nanofibers. No. 2013-145. Centers for Disease Control and Prevention, 2013. Disponibile al sito http://www.cdc.gov/niosh/docs/2013-145/.
16) Manno M, Viau C, in collaboration with Cocker J et al. Biomonitoring for occupational health risk assessment (BOHRA). Toxicol Lett 2010; 192(1): 3-16. DOI: https://doi.org/10.1016/j.toxlet.2009.05.001
17) lavicoli I, Leso V, Manno M, et al. Biomarkers of nanomaterial exposure and effect: current status. J Nanopart Res 2014; 16: 2302. 18) Schulte P, Leso V, Niang M, et al. Biological monitoring of workers exposed to engineered nanomaterials. Toxicol Lett. 2018; 298: 112-124. 19) Liguori B, Hansen SF, Baun A, et al. Control banding tools for occupational exposure assessment of nanomaterials - Ready for use in a regulatory context? Nanolmpact 2016; 2: 1-17. DOI: https://doi.org/10.1016/j.toxlet.2018.06.003
20) Balas F, Arruebo M, Urrutia J, et al. Reported nanosafety practices in research laboratories worldwide. Nat Nanotechnol 2010; 5(2): 93-96. DOI: https://doi.org/10.1038/nnano.2010.1

How to Cite



[Nanoparticle exposure in research labs]. (2019). Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 41(4), 349-353. https://doi.org/10.4081/gimle.521
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