[Reference values: from guide values to the exposome]
Valori di riferimento: dai valori guida all’esposoma
Published: March 3 2025
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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The correspondence between biomarkers and the complex interaction of toxics with the human organism has been fully described years ago by the American National Research Council which developed a precious diagram.
This model is still valid in describing the new methodologic agnostic or "omic" approaches to the science of exposure. Reference values and exposome share indeed the search for internal dose biomarkers; adduttomics may be seen as an evolution of the target dose markers while epigenetics itself is a new way of exploring the world of early effect biomarkers.
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Citations
1) Biological markers in environmental health research. Committee on Biological Markers of the National Research Council. Environmental Health Perspectives 1987; 74: 3-9. DOI: https://doi.org/10.1289/ehp.87743
2) Sunderman F William. Current concepts of "normal values", "reference values" and "discrimination values" in clinical chemistry. 1975; 1873-1877. DOI: https://doi.org/10.1093/clinchem/21.13.1873
3) Vesterberg O, Alessio L, Brune D, Gerhardsson L, Herber R, Kazantzis G, Nordberg GF, Sabbioni E. International project for producing reference values for concentrations of trace elements in human blood and urine—TRACY. Scand J Work Environ Health 1993; 19 Suppl 1: 19-26.
4) Apostoli P. Criteria for the definition of reference values for toxic metals. Science of the total environment 1992; 120, 1-2: 23-37. DOI: https://doi.org/10.1016/0048-9697(92)90214-D
5) Apostoli P, Minoia C. I valori di riferimento in medicina occupazionale ed ambientale. G Ital Med Lav Ergon 1999; 21(1): 25-39.
6) Minoia C, Apostoli P. 1^ a lista SIVR dei valori di riferimento: definizioni, criteri metodologici e strategie analitiche. G Ital Med Lav Ergon 2003; 25(1): 15-21.
7) Gräsbeck R. The evolution of the reference value concept. Clin Chem Lab Med 2004; 42(7): 692-7. DOI: https://doi.org/10.1515/CCLM.2004.118
8) Siest G, Henny J, Gräsbeck R, Wilding P, Petitclerc C, Queraltó JM, Hyltoft Petersen P. The theory of reference values: an unfinished symphony. Clin Chem Lab Med 2013 Jan; 51(1): 47-64. DOI: https://doi.org/10.1515/cclm-2012-0682
9) Aprea, Maria Cristina, et al. La metodologia per la definizione dei Valori di Riferimento Biologici in campo ambientale e occupazionale: il contributo della Società Italiana Valori di Riferimento (SIVR). La Medicina del Lavoro 2017; 108.2: 138-148.
10) https://www.cdc.gov/nchs/nhanes/ 11) http://www.umweltbundesamt.de/en/topics/health/assessing-environmentally-related-health-Risks/german-environmental-survey-geres.) 12) Berlin A, Yodaiken RE, Logan DC. International seminar on the assessment of toxic agents at the workplace roles of ambient and biological monitoring, Luxembourg, 8-12 December, 1980. Summary report. Int Arch Occup Environ Health 1982; 50(2): 197-207. DOI: https://doi.org/10.1007/BF00378081
13) Miraglia N, Assennato G, Clonfero E, Fustinoni S, Sannolo N. [Biologically effective dose biomarkers]. G Ital Med Lav Ergon 2004 Oct-Dec; 26(4): 298-301.
14) Motta V, Bonzini M, Grevendonk L, lodice S, Bollati V. Epigenetics applied to epidemiology: investigating environmental factors and lifestyle influence on human health. Med Lav 2017 Feb 15; 108(1): 10-23.
15) Bollati V, Baccarelli A. Environmental epigenetics. Heredity (Edinb). 2010 Jul; 105(1): 105-12. DOI: https://doi.org/10.1038/hdy.2010.2
16) Rappaport SM. Implications of the exposome for exposure science. Journal of Exposure Science and Environmental Epidemiology 2011; 21.1: 5-9. DOI: https://doi.org/10.1038/jes.2010.50
17) Wild CP. Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiology Biomarkers & Prevention 2005; 14.8: 1847-1850.
18) Wild CP. The exposome: from concept to utility. International journal of epidemiology 2012; 41.1: 24-32. DOI: https://doi.org/10.1093/ije/dyr236
19) Wild CP. Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. 2005: 1847-1850. DOI: https://doi.org/10.1158/1055-9965.EPI-05-0456
20) Paganelli M, De Palma G, Apostoli P. Esposoma: da intuizione a linea di ricerca obbligata nelle scienze mediche occupazionali e ambientali. G Ital Med Lav Ergon 2017; 34(2): 68-71. DOI: https://doi.org/10.4081/gimle.606
21) Vineis P, Chadeau-Hyam M, Gmuender H, et al. The exposome in practice: design of the EXPOsOMICS project. International Journal of Hygiene and EnvironmentalHealth. 2016. DOI: https://doi.org/10.1016/j.ijheh.2016.08.001
22) Vrijheid M, Slama R, Robinson O, et al. The human early-life exposome (HELIX): project rationale and design. Environmental health perspectives 2014; 122.6: 535-544.
How to Cite
[Reference values: from guide values to the exposome]: Valori di riferimento: dai valori guida all’esposoma. (2025). Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 39(3), 159-161. https://doi.org/10.4081/gimle.622
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