Original Articles
8 April 2025
Vol. 37 No. 1 (2015)
[Amyotrophic lateral sclerosis and exposure to metals and other occupational/environmental risk agents: state of the art]
Sclerosi laterale amiotrofica ed esposizione a metalli ed altri agenti di rischio di natura occupazionale/ambientale: stato dell’arte
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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In recent years, scientific literature has been giving more and more importance to the study of the occupational/environmental exposure to risk agents related to the onset of Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex. Aim of this work is to verify the state of art about the eventual role of occupationall environmental exposure to risk agents. Selected articles, on the basis of keywords, year of publication and topics, are related to occupational and environmental exposure to xenobiotics, and, in particular, to the exposure to heavy metals that could lead to neuronal damage mechanisms involved in ALS onset. The review shows that although the scientific production has increased the interest in the evaluation of extra-genetic causes of ALS onset, there are still few studies concerning the careful study of the work activities of the individual patient, and the inferences that can be drawn to date about the possible connection between occupational exposure to risk factors and the onset of ALS are still lacking.
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How to Cite
[Amyotrophic lateral sclerosis and exposure to metals and other occupational/environmental risk agents: state of the art]: Sclerosi laterale amiotrofica ed esposizione a metalli ed altri agenti di rischio di natura occupazionale/ambientale: stato dell’arte. (2025). Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 37(1), 8-19. https://doi.org/10.4081/gimle.673
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