ATTI 79° CONGRESSO NAZIONALE SIML
15 April 2025
Vol. 38 No. 3 (2016)
Critical research needs to address occupational safety and health of nanomaterial workers
[La ricerca critica deve affrontare la sicurezza e la salute sul lavoro dei lavoratori che utilizzano nanomateriali]
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
1
Views
2
Downloads
Authors
Conceptually, the initial phase of nanomaterial occupational safety and health research is now largely completed and the next phase targeting more refined research is starting. The pending question is what is the critical research that should be conducted to move the field forward and advance worker protection. Research is needed to further understand toxic effects of nanomaterials. There is also need for more exposure data, and for data on the prevalence of the use of controls to prevent worker exposures. One growing area that needs attention is determination of ENM exposure in additive manufacturing. Overall, for the nanomaterial workforce enough time has now passed to consider and implement more rigorous longitudinal epidemiological studies of various groups of workers. Additionally, special attention needs to be continued for investigation of hazard risk and control of exposure to high aspect ratio nanomaterials. Most importantly, there is need for continued refinement of strategies to group nanomaterials and develop categorical risk management guidance.
Altmetrics
Downloads
Download data is not yet available.
Citations
Arts JHE, Hadi M, Keene AM et al. A critical appraisal of existing concepts of grouping of nanomaterials. Reg Tox Pharmacol 2014; 70:
Azimi P, Zhao D, Pouzet C, Crain NE, Stephens B. Emissions of Ultrafine Particles and Volatile Organic Compounds from Commercially Available Desktop Three-Dimensional Printers with Multiple Filaments. Environ Sci Technol 2016; 50: 1260-1268.
Campbell T, Williams C, Ivanova O, Garrett B. Could 3D printing change the world technologies, potential, and implications of additive manufacturing. Atlantic Council, Washington, DC. 2011.
Campbell TA, Ivanova OS. Additive manufacturing as a disruptive technology: implications of three-dimensional printing technology & innovation 2013; 15: 67-79.
Connor BP, Manogharan GP, Martof AN, Rodomsky LM, Rodomsky CM, Jordan DC, Limperos JW. Making sense of 3-D printing: creating a map of additive manufacturing products and services. Additive Manufacturing 2014; 1-4: 64-76 doi:10.1016/j.addma.2014.08.005 Fatkhutdinova LM, Khaliullin TO, Vasil'yeva OL, Zalyalov RR, Mustafin IG, Kisin ER, Birch ME, Yanamala N, Shvedova AA. Fibrosis biomarkers in workers exposed to MWCNTs. Toxicol Appl Pharmacol 2016; 299: 125-131.
Froggett SJ, Clancy SA, Boverhof DR et al [2014]. A review and perspective of existing research on the release of nanomaterials from solid nanocomposites. Particle and Fibre Toxicology 2014; 11:17. Geraci C, Heidel D, Sayes C, Hodson L, Schulte P, Eastlake A, Brenners S. Perspectives on the designs of safer nanomaterials and manufacturing processes. J Nanopart Res 2015.
Grosse Y, Loomis D, Guyton KZ, Lauby-Secretan, El Ghissassi F, Gula N, Scoccianti C, Mattlock H, Strait K. Carcinogenicity of fluoroedenite, silicon canbide fibres and whiskers, and carbon nanotubes. Lancet Oncol 2014; 15 (13): 1427-1428.
Gu DD, Meiners w, Wissenbach K, Poprawe R. Laser additive manufacturing of metallic components: materials, processes and mechanisms. International Materials Reviews 2012; 57:133-164.
Heitbrink WA, Lo L-M. Effects of carbon nanotubes upon emissions from cutting and sanding carbon fiber-epoxy composites. J Nanopart Res 2015; 17:335.
Ivanova O, Williams C, Campbell T. Additive manufacturing (AM) and nanotechnology: promises and challenges. Rapid Prototyping Journal 2013; 19: 353-364 Kim Y, Yoon C, Ham S, Park J, Kim S. Kwon O, Tsai PJ. Emissions of nanoparticles and gaseous materials from 3D printer operation. Environ Sci Technol 2015; 49:12044-12053.
Krug HF. Nanosafety research—are we on the track? Angew Chem 2014: 53:12304-12319.
Suempel ED, Castranova V, Geraci CL, Schulte PA. Development o isk-based nanomaterial groups for occupational exposure control. Nanopart Res 2012a; 14:1-15.
Kuempel ED, Geraci CL, Schulte PA. Risk assessment and risk management of nanomaterials in the workplace: translating research to practice. Ann Occup Hyg 2012; 56(5): 491-505.
Kuempel ED, Jaurand MC, Moller P, Morimoto Y, Kobayashi N, Pinkerton KE, Sargent LM, Vermeulen RCH, Fubini B, Kane A. Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. Critical Reviews in Toxicity 2016. DOI 10.1080/10408444.2016.1206061. Liou SH, Tsai CSJ, Pelclova D, Schubauer-Berigan MK, Schulte PA. Assessing the first wave of epidemiological studies of carbon nanomaterial workers. J Nanopart Res 2015; 17:1-19.
Maynard AD, Aitken RJ, Butz T, Colvin V, Donaldson K, Oberdörster G, Philbert MA, Ryan J, Seaton A, Stone V, Tinkle SS, Tran L, Walker, NJ, Warheit DB. Safe handling of nanotechnology. Nature 2006; 444 (7117): 267-269.
Maynard AD. Are we ready for spray-on carbon nanotubes. Nature Nanotechnology 2016; 11: 490-491.
Murr LE et al. Metal fabrication by additive manufacturing using laser and electron beam melting technologies. Journal of Materials Science & Technology 2012; 28: 1-14.
National Science and Technology Council (2013). National Network for Manufacturing Innovation: a preliminary design. http://www.manufacturing.gov/files/2015/12/NNMI_prelim_design.pdf NIOSH. Strategic plan for NIOSH nanotechnology research and guidance. Cincinnati, OH. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Publication No 2010-105. Oberdörster G, Castranova V, Abgharian B, Sayre P: Inhalation exposure to carbon nanotubes (NT) and carbon nanofibers (CNF): Methodology and dosimetry. J Toxicol Environ Health, Part B 18: 3-4, 121-212.
OECD. Testing programme of manufactured nanomaterials overview. https://www.oecd.org/chemicalsafety/nanosafety/overview-testingprogramme-manufactured-nanomaterials.htm. Date Accessed June 27, 2016.
Riediker M, Schubauer-Berigan MK, Brower DH et al: A road map toward a globally harmonized approach for occupational health surveillance and epidemiology in nanomaterial workers. J Occup Environ Med 2012; 54: 1214-1223.
Sargent LM et al. Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes. Part Fibre Toxicol 2014; 11:b114.
Savolainen K, Pylkkänen L, Norppa H, Falck G, Lindberg H, Tuomi T et al. Nanotechnologies, engineered nanomaterials health and safety a review. Safety Sci 2010; 48: 959-963.
Savolainen K, Alenius H, Norppalt, Pylkkänen L, Tuomi T, Kasper G: Riask assessment of engineered nanomaterials and nanotechnologies a review. Toxicol 2010; 269: 92-104.
Schulte PA, lavicoli I, Rantanen JH, Dahmann D, lavicoli S, Pipke R et al. Assessing the protection of the nanomaterial workforce. Nanotoxicology. 2016; 10(7):1013-9.
Schulte PA, Roth G, Hodson L, Murashov V, Hoover M, Zumwalde R, Kuempel E, Geraci C, Stefaniak A, Castranova V, Howard J. Taking stock of the occupational safety and health challenges of nanotechnology 2000-2015. J Nanopart Res (2016a). DOI 10.1007/51/1051-016-3459-1.
Schulte PA, Kuempel ED, Zumwalde RD et al: Focused actions to protect carbon nanotube workers. Am J Ind 2012; 55: 395-411.
Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich Al et al (2005). Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. AM J Physiol Lung Cell Mol Physiol 289(5):L698-L708.
Shedova AA, Yanamala N, Kisin ER, Khailullin TO, Birch ME, Fatkhutdinova LM. Integrated analysis of dysregulated NcRNA and mcRNA expression profiles in humans exposed to carbon nanotubes. PLOS ONE DOI: 10.1371/journalepone.0150628. March 1, 2016.
Suzui M, Futakuchi M, Fukamchi K, et al: Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce pleural malignant mesothelioma and lung tumors. Cancer Sci 2016. DOI: 10/1111/cas.12954
Weldon BA, Faustman EM, Oberdorster G et al. Occupational exposure limit for silver nanoparticles: considerations on the derivation of a general health-based value. Nanotoxicology 2016; 10(7): 945-56.
How to Cite
Critical research needs to address occupational safety and health of nanomaterial workers: [La ricerca critica deve affrontare la sicurezza e la salute sul lavoro dei lavoratori che utilizzano nanomateriali]. (2025). Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 38(3), 151-154. https://doi.org/10.4081/gimle.685
Copyright (c) 2016 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.